New Antimicrobial On The Block

ainesville, Fla.-based Quick-Med Technologies Inc., developer of antimicrobial and
matrix-metalloproteinase-inhibitor (MMPI) technologies that have applications in healthcare,
consumer and industrial markets, has introduced Stay Fresh™ antimicrobial technology developed
specifically for textiles. The company reports the new technology features an eco-friendly active
ingredient in a skin-friendly formulation, and provides unsurpassed durability and efficacy in
killing a very broad spectrum of pathogens — including both Gram-positive and Gram-negative
bacteria, as well as fungi and viruses — even after as many as 75 home launderings. The formula,
which can be applied using conventional processes to fabrics made with a wide range of natural and
man-made fibers, also is claimed to brighten colors and facilitate the cleaning process.

Potential applications for Quick-Med’s Stay Fresh™ antimicrobial technology pictured above
include fabrics and pulp for hygiene and medical applications, infants’ and children’s wear,
pajamas, socks, T-shirts and surgical scrubs.

While the company will not divulge the technology’s active ingredient because patents are
pending, Dr. Jerry Olderman, vice president of research and development, did list a number of
antimicrobial substances it is not: “It’s not anything that’s being sold for textile use today,
such as silver, copper, triclosan, biguanides, cationic lipids, organic halides, light-activated
antimicrobials or other substances. All those things it is not come with their own special
shortcomings,” he said, noting such issues as limited spectrum efficacy, durability beyond only a
few launderings, discoloration of the textile and environmental issues related to various
established technologies. “In addition, Stay Fresh is durable to bleach; and is nonleaching,
nontoxic and OSHA [Occupational Safety and Health Administration]-compliant.”

Olderman said the active chemistry is already being used on a different material and is
registered with the Environmental Protection Agency (EPA) registration for that use. Quick-Med is
in the process of applying for EPA registration for the new textile use. The company also will be
seeking approval from the Food and Drug Administration for certain medical textile applications. In
the meantime, said Quick-Med CEO J. Ladd Greeno, the company is offering the technology for its
ability to destroy odor- and stain-causing bacteria and fungi.

Quick-Med’s product platforms also include two other technologies: NIMBUS® (novel
intrinsically micro-bonded utility substrate), which uses advanced antimicrobial polymers that
destroy bacteria at the cellular level and has FDA approval for use in wound dressings and related
products; and MultiStat® MMPI technology, which inhibits MMP production in the skin that is
triggered by chemicals, sun exposure and natural aging. Stay Fresh is an outgrowth of NIMBUS, but
is a completely different technology for textile use, Greeno said.

How It Works

Asked about the technology’s effect on beneficial bacteria, Greeno explained: “The treatment
is on the textile, and it controls bacteria in the treated textile. It won’t leach into the skin
surface, and it won’t cause problems with home laundry water effluent,” he added noting reports of
silver washing off in the laundry under certain circumstances.

“The mechanism of destruction is very different from cations, which break the cell wall and
membrane so that the walls fall apart, the cell collapses and its contents leak out, and the cell
is no longer viable,” Olderman said. “Stay Fresh technology works on the outside of the cell, and
destroys the chemistry of the cell wall, converting the cell components to inert, nonviable

Greeno noted that garments treated with Stay Fresh can be laundered in hot or cold water
using anionic detergents offered widely for home laundering, with or without chlorine or
non-chlorine bleach, without impacting its efficacy or causing discoloration. “Many antimicrobials
are blinded by some of the popular detergents and softeners,” he said.

Stay Fresh is applied to the fabric using a conventional padding process. “The finishing
process can be combined with other finishing steps including softening, wicking and/or antistatic
treatments,” Greeno said. “The finishing process is compatible with other activities and equipment
in the mill, and the cost of the substance is low, so the overall cost is a fraction of the cost of
other technologies.”

Downstream Use

Greeno said Quick-Med is working with a range of customers to bring Stay Fresh to consumers.
“We developed the technology and will license it to customers. We are targeting broadly essential
apparel such as underwear, T-shirts, socks and intimate apparel; sportswear for both the casual
sports enthusiast and the serious user; uniforms for utility workers, first responders and service
workers; and bed linens and towels. We’re looking at both consumer and commercial markets, and have
had discussions with customers in each of those areas. We think Stay Fresh really runs circles
around what’s currently available and can offer our customers a way to differentiate their
products,” he said.

One customer is a cotton apparel manufacturer that plans to use Stay Fresh for an underwear
application for a government agency. “The customer set extremely rigorous requirements,” Olderman
said. “Nothing up to now has proven acceptable, and the closest is too expensive. After five months
of third-party testing and four trials, the customer found that Stay Fresh met all its
requirements, and will replace its current solution with Stay Fresh once its current inventory is

For more information about Stay Fresh™, contact J. Ladd Greeno +888-835-2211 Ext. 102;

December 2009